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Scientific and technical events communicated by the federation FRABio


Conferences, seminars, meetings, demonstrations, presentations, thematic sessions, workshops …

27th june 2017

( Seminar #9 )

"Structural and functional studies on glycosyltransferase dimers"


Séminar led by Dr. Tuomo Glumoff, University Lecturer, Adjunct Professor, and the Dean of Education at the Faculty of Biochemistry and Molecular Medicine of the University of Oulu in Finland.

The visit is made possible by support from the Institut Francais de Finlande, the Embassy of France in Finland, the French Ministry of Education, Higher Education and Research and the Finnish Society of Science and Letters.

Abstract : Glycosyltransferases (GTases) transfer sugar moieties to/from glycan or polysaccharide molecules. GTases form an important group of enzymes in the Golgi, where synthesis and modification of glycoproteins and glycolipids take place. Golgi GTases are almost invariably type II integral membrane proteins with the C-terminal globular catalytic domain located in the Golgi lumen. GTases are divided into 103 families based on their sequences, and there is an abundance of crystal structures of the catalytic domains. All of these domains possess either of the two characteristic folds, GT-A or GT-B, or present a variation thereof. Since it is known that GTases can function as dimers in vivo, we have analysed the dimerization interface in crystal structures of GTases in the light of available biochemical data. Initially all 898 GTase crystal structures in the Protein Data Bank were considered and a set of 24 enzymes analysed in detail. Results from structure-function studies of GTases will be discussed..

10:00 AM | Location 1 : IRI-IRCICA Building, amphitheater, 50 Halley Avenue, Haute Borne Scientific, University Lille 1, Villeneuve d'Ascq (access map N°50)

 

( Seminar #8 )

"STIM2-STIM1 interactions in regulation of Orai1 – Tuning the sensitivity of store-operated Ca2+ entry."


Seminar led by Doctor Indu AMBUDKAR, Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda US.

Invited by Prof. Natalia Prevarskaya, Laboratory of Cell Physiology INSERM U 1003 Université de Lille 1,

Résumé : Dr Ambudkar is chief of the Secretory Physiology Section and chief of the Molecular Physiology and Therapeutics Branch in NIDCR NIH Bethesda, US. She is one of the main specialist in the study of the role of Ca2+ signals and Transient Receptor Potential Channels in several axpects of cell physiology with particular interest in salivary gland fluid secretion. In her scientific career che uncovered the role of some key componets components that mediate and regulate Ca2+ entry into salivary gland cells and characterize the role of these in normal physiology as well as dysfunction/disease of salivary glands. Most of her studies have been directed directed towards identifying the function, regulation, trafficking and assembly of the transient receptor potential channel, TRPC1. She have provided evidence that TRPC1 is an essential component of the agonist-stimulated Ca2+ influx mechanism that is required for sustained saliva secretion. She identified two other important components of this mechanism, the calcium channel, Orai1, and the ER regulator of calcium channels, STIM1. Current studies are directed to understand and define the individual contributions of TRPC1 and Orai1 to salivary fluid secretion. Moreover interested in identifying the regulation of the water channel, AQP5, during stimulation of the gland and secretion. Her work has led to the identification of TRPV4 as an essential TRP channel that is involved in cellular volume regulation. In addition other TRPC channels, TRPC3 and TRPC6, could also have important role in regulating other aspects of salivary gland function.

10:00 AM | Location 2 : Department of Biology, building SN3, Room PASTEUR, Scientific City, University Lille 1, Villeneuve d'Ascq (access map > area 5)

 
23th may 2017

( Scientific Meeting )

"Scientific Meeting of the Proteomics & Mass Spectrometry Platforms" (Platform in Biology & Health of Lille)

Due to the security measures taken to enter the Pasteur Campus, you are requested to report your participation in the scientific meeting to Stéphanie Devassine (stephanie.devassine@univ-lille1.fr) no later than Monday, May 22 at 12:00.


PROGRAM

13h00 - 13h30 Accueil
  • 13h30 - 13h50 "Apports de la protéomique pour caractériser le rôle de la O-GlcNAcylation dans la physiologie musculaire".
    Animé par Caroline CIENIEWSKI-BERNARD, EA7369-URePSSS, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Université Lille 2
    Plateau : Centre de Spectrométrie de Masse & Analyse Protéomique de l’Artois
  • 13h50 - 14h10 "Utilisation des aptamères (dosage Somascan) pour l'approche multi-marqueurs".
    Animé par Florence PINET, INSERM U1167, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Institut Pasteur de Lille
    PlateauProtéomique - U1167
  • 14h10 - 14h30 "Élucidation du contenu en protéines nucléaires des spermatozoides bovins en lien avec la fertilité".
    Animé par Chrystelle LE DANVIC, ALLICE, Département R&D
    Plateau : TOP OMICS & HIGH MASS

  • 14h30 - 15h30 "Introduction la plateforme protéomique de l'Institut Jacques Monod, ses missions et ses modalités de fonctionnement. Analyses protéomiques de l'apoptose induite par une molécule de quorum-sensing chez la levure pathogène Candida albicans".
    Animé par Jean-Michel CAMADRO, CNRS UMR7592, Institut Jacques Monod, Université Paris-Diderot, Paris
15h30 - 16h00 Pause
  • 16h00 - 16h20 "Auto-anticorps et fibrogenèse dans la sclérodermie systémique : approche par protéomique".
    Animé par Solange VIVIER, INSERM U995, LIRIC, Lille Inflammation Research International Center, Université Lille 2
    Plateau : Protéomique & Electrophorèse Haute Résolution de Lille
  • 16h20 - 16h40 "Apport de l'imagerie MALDI pour l'analyse des lésions PanINs dans des modèles murins de cancer du pancréas (en collaboration avec Centre de recherche Jean-Pierre Aubert INSERM UMR1172)"
    Animé par Soulaimane ABOULOUARD, INSERM U1192, Protéomique, réponse inflammatoire et spectrométrie de Masse (PRISM), Université Lille 1
    Plateau : CLIC-IMAGING
  • 16h40 - 17h00 "Apport du MALDI-QIT-TOF-MS pour l'analyse structurale des glycannes perméthylés".
    Animé par Bernadette CODDEVILLE, CNRS UMR8576, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université Lille 1
    Plateau : PAGES (Analyse des Glycoconjugués)
  • 17h00 - 17h20 "La synthèse totale de hSUMO-3 et son analyse par spectrométrie de masse".
    Animée par Jennifer BOUCHENNA, CNRS UMR8161, Approches Génétiques, Fonctionnelles et Structurales des Cancers, Institut de Biologie de Lille
    Plateau : Chemistry Systems Biology platform


1:00 PM - 5:20 PM | Location : Biology Institute of Lille, Main amphitheater, "Grand Palais" Subway station, Lille (North of France)

 

12th may 2017

( Seminar #7 )

"Sex differences in Ketamine's antidepressant effect"


Seminar led by Professor Mohamed Kabbaj, College of Medicine - Florida State University - USA

Invited by the Team " Glycobiologie des Maladies Liées au Stress".

Summary : "Current medications for major depression suffer from numerous limitations and take several weeks to improve mood. However, recent clinical studies have shown that a single low-dose injection of ketamine, an N-methyl d-aspartate receptor (NMDAR) antagonist, has rapid antidepressant effects that are observed within hours and are long lasting, even in patients who do not respond well to various other anti-depressants. In this lecture, I will share some of our preclinical findings regarding sex differences in ketamine antidepressant effects and the role of gonadal hormones in these differences. I will also briefly share some of the recent findings surrounding the safety of ketamine as treatment for depression".

Biographical sketch: Professor Kabbaj earned his Ph.D. at Bordeaux II University (France) under the supervision of Professor Stefania Maccari, and then completed five years of postdoctoral study at the Mental Health Research Institute at the University of Michigan (Ann Arbor) with Dr. Huda Akil. Then, Dr. Kabbaj joined the department of biomedical sciences at the Florida State University College of Medicine in August 2002 where he went through the academic ranks, and was promoted full professor with tenure at FSU in 2012. Dr. Kabbaj's research focus on understanding the neurobiology underlying individual differences and sex differences in depression and drug addiction. Another focus of his research is to examine epigenetic mechanisms underlying social behaviors in the monogamous specie prairie voles. Dr. Kabbaj has more than 80 publications, many of which are in excellent journals like Nature Neuroscience, Neuron, Journal of Neuroscience, etc. Dr. Kabbaj has been funded throughout his career by grants from the National Institute of Mental Health and the National Institute of Drug addiction.

11:00 AM | Location : UFR de Biologie, building C9 - Room Bernard Fournet, Scientific City, University Lille 1, Villeneuve d'Ascq (map)

 
7th april 2017

( Seminar #6 )

"A rational approach to small-molecule protein aggregation inhibitors in neurodegenerative diseases"


Seminar led by Professor Gal Bitan, University of California - Los Angeles - USA
David Geffen School of Medicine at UCLA, Department of Neurology.

Invited to the UGSF's seminars by the "RMN et interactions moléculaires - Labex Distalz" team.

11:00 AM | Location : IRI-IRCICA Building, 50 Halley Avenue, Haute Borne Scientific, University Lille 1, Villeneuve d'Ascq (access map N°50)

 
24th march 2017

( Seminar #5 )

"The role of Protein Phosphorylation and protein-protein interactions in regulating starch biosynthesis"


Seminar led by Professor Michael J. EMES (University of Guelph, Canada), visiting professor at the University of Lille 1.

Invited by the "Vegetal Glycobiology" group.

Abstract : "Starch is a major source of calories for humankind and yet there remain significant gaps in our knowledge about how it is synthesised in plants. Cereal seeds accounts for about 90% of all agriculturally produced starch on the planet, where it is synthesised in amyloplasts of developing endosperm prior to maturation. Biosynthesis involves at least three classes of stromal enzymes to produce the insoluble, highly organised, semi-crystalline structure of amylopectin, which is the major glucan polymer of starch. Starch synthases, starch branching enzymes and debranching enzymes are found as multiple, stromal isoforms whose activities within the amyloplasts must be tightly coordinated in order to form repeating glucan clusters, reproducibly. In this presentation, I will review the evidence that at least some classes of starch synthases and starch branching enzymes form heteromeric enzyme complexes whose association is regulated by protein phosphorylation. Biochemical and cell biological approaches have been used, along with the study of mutants, to understand the centrality of these mechanisms to starch synthesis and how disruption of these interactions can affect starch structure."


11:00 AM | Location : IRI-IRCICA Building, 50 Halley Avenue, Haute Borne Scientific, University Lille 1, Villeneuve d'Ascq (access map N°50)

 
10th february 2017

( Seminar #4 )

"PDBe – Bringing structure to biology"
,

Dear all, It is our pleasure to announce a presentation by: Sameer Velankar team leader at the EBI and current director of the Protein Data Bank in Europe. Location and time : Friday, 10th February at 11.00am Amphitheater CCHB Campus CNRS Haute-Borne 50 avenue de Halley 59658 Villeneuve d'Ascq

Abstract : The Protein Data Bank in Europe (PDBe; pdbe.org) is a founding member of Worldwide Protein Data Bank (wwPDB;http://www.wwpdb.org) organization that manages the Protein Data Bank (PDB). Realising the challenges faced by the wider user community in accessing and exploiting structural data, PDBe has focused on the following major areas – • Improving data quality for entries in the PDB and enriching structural data with annotations to provide biological context • Implementing efficient data-discovery mechanisms • Intuitive and consistent data presentation We have developed a powerful query system that allows users to not only query structural data but also shows the “best structures” for a given protein, ligand complex or Pfam sequence family using the validation information available in the wwPDB validation reports. The entry information is made available via a PDBe RESTful API that provides unified access to the PDB and EMDB archives. The value added annotations on data quality and up-to-date cross reference information from the SIFTS resource is also made accessible via the RESTful API to support large scale data analysis. The information is also made available at the PDBe website via an intuitive and interactive user interface. In this presentation, I will present our efforts to fulfill our mission of “Bringing structure to biology” by making structural data accessible to wider scientific community.

Best regards Guillaume Brysbaert

11:00 AM | Location : IRI-IRCICA Building, 50 Halley Avenue, Haute Borne Scientific, University Lille 1, Villeneuve d'Ascq (access map N°50)

 
7th february 2017

( Seminar #3 )

"Glycan signatures : Interests and Applications of Glycoprofiles on Lectins"
,

Seminar led by Ludovic LANDEMARRE / GLYcoDiag Society (Chevilly, France)

Invited by Dr. Julie Bouckaert (UGSF – UMR8576)


2:00 PM | Location : IRI-IRCICA Building, 50 Halley Avenue, Haute Borne Scientific , Université Lille 1, Villeneuve d'Ascq (access map N°50)

 
3rd february 2017

( Seminar #2 )

"Assessing the effect of Single Nucleotide Variants on the expression of key human genes"
,

Seminar led by Pr. Merlin Crossley (University of New South Wales, Sydney, Australia).

Merlin’s lab has used CRISPR and TALEN-mediated genome editing to study naturally occurring mutations that alter the expression of genes involved in human genetic diseases, such as haemophilia and sickle cell anaemia. The introduction of beneficial mutations associated with increased expression of foetal haemoglobin (Hereditary Persistence of Foetal Haemoglobin) represents a novel therapeutic strategy. In some instances the introduction of natural mutations may be preferable to gene replacement therapy.

Invité dans le cadre des séminaires de l’UGSF (Dr. Alexis Verger - Equipe Biologie Structurale et Intégrative)

Location : IRI-IRCICA Building, 50 Halley Avenue, Haute Borne Scientific, University Lille 1, Villeneuve d'Ascq (access map N°50)

 
13th january 2017

( Seminar #1 )

"Study of the Polycomb repression in the zebrafish model"
,

Seminar led by Pr. Pierre-Olivier ANGRAND, U908 INSERM « Plasticité Cellulaire et Cancer » (University of Lille, Sciences et Technologies).

Invited by Dr. Anne Harduin (UGSF - UMR CNRS 8576 / Equipe Régulation de la glycosylation terminale).

Location : IRI-IRCICA Building, 50 Halley Avenue, Haute Borne Scientific, University Lille 1, Villeneuve d'Ascq (access map N°50)

 
23th november 2016

( Thematic morning)

"Transmission Electron Microscopy in the Service of Research. Applications in Life Sciences and Material Sciences."

Life Sciences and Materials Science use many common analysis technologies such as mass spectrometry, NMR, X-ray crystallography, and electron microscopy. In recent years, the "Science and Technology" campus of the University of Lille has set up a advanced technological equipment in transmission electron microscopy (TEM), with high performance complementary, which led to Interactions and exchanges of skills between the staff of the platforms of the two federations. This morning aims to better inform the users of the two scientific communities on the existence of this material park and its possibilities, as well as to encourage exchanges between researchers, teacher-researchers, technical staff, etc., from Life Sciences and Materials Science. During this morning, you will be presented the two platforms of electron microcopy of the campus of the University of Lille "Science and Technology", with multiple examples of applications in their respective fields. These presentations will be followed by 2 lectures led by speakers of international renown, illustrating the ultimate possibilities of each of the two disciplines.

Wishing to see you at this event.

Dominique Legrand & Guy Buntinx, Directors of Federations FRABio (FR3688) and Chevreul (FR2698)


>>
Only on registration <<


1 - PROGRAM

Download the program (in french)

Welcoming and opening (from 9:00 am)

Introduction (9:15 - 10:45)

  • 9:15 - 9:30 Introduction of the morning by the Directors of the FRABio & Chevreul Federations
    (Dominique Legrand & Guy Buntinx, directors of FRABio & Chevreul Federations)
  • 9:30 - 9:45 Presentation of the FRABio's Electron Microscopy Platform (Loïc Brunet, TEM technical manager of the BICeL - Campus Lille1 platform)
  • 9:45 - 10:00 Applications of Transmission Electron Microscopy in Biology: molecular and elementary markings in normal cells and in degeneration
    (Christian Slomianny, Scientific Director of the BICeL Campus Lille1 platform)
  • 10:00 - 10:15 Presentation of the Electron Microscopy platform - Chevreul Federation
    (Damien Jacob, Head of the Chevreul TEM platform)
  • 10:15 - 10:30 Applications of Transmission Electron Microscopy in Materials Science: Localization of metallic nanoparticles in materials with hierarchical porosity
    (Jean-Philippe Dacquin, UCCS)
  • 10:30 - 10:45 Applications of Transmission Electron Microscopy in Materials Science: The origins of organic matter in meteorites and the solar system addressed by the MET / spectroscopy coupling
    (Corentin Le Guilliou, UMET)
  • Coffee break

Invited conférences (11:10 - 12:30)

  • 11:10 - 11:50 “Model-based Dark-field STEM: from images towards precise atomic structures in two and three dimensions”.
    Sandra Van Aert, Professor at the EMAT (University of Antwerp, Belgium).
  • 11:50 - 12:30 "Beyond the micron in bio-medicine".
    Sergio Marco-Garrido, Facilitated by Sergio Marco-Garrido, Inserm Research Director at the Institut Curie (Orsay, France)

Conclusion

Buffet lunch
(Pasteur Room - PolyTech’Lille building)


2 - CONDITIONS OF PARTICIPATION & REGISTRATION

Participation in this event is free but registration is required so that we can ensure the logistics.

The registration form is closed


Contact : Dominique Legrand (Director of the Federation CNRS 3688 FRABio)

9:00 - 13:00 | Polytech’Lille building, Amphitheater "Appert", Scientific City, University Lille 1, Villeneuve d'Ascq (access map > area 7)

 


 
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